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June 23, 2016

Dr. Charles P. Xavier Takes the Robert A. Phillips Award and a Navy-wide Academic Research Competition Award

by Paula Amann
Published in the June 2016 issue of Military Medical Research News, a monthly newsletter of the Department of Research Programs, Walter Reed National Military Medical Center.

Fine-tuning facial transplants, predicting bone fractures, shrinking prostate cancers with new drugs and cutting the costs of surgical training with the right technology: These were among the problems probed by competition winners for 2016 Research and Innovation Month at Walter Reed National Military Medical Center (WRNMMC).

The events, during Poster Display Week on May 11 and the Research Symposia on May 18-19, drew abstracts for 178 projects. After winnowing by pre-selection judges, 22 finalists emerged in three categories: case reports, evidence-based practice and quality improvement (a crucial non-research area).

Another 24 finalists, split evenly between laboratory and clinical research, vied for the Robert A. Phillips (RAP) and Bailey K. Ashford (BKA) Awards. The two BKA winners were LCDR Gabriel Santiago, MC (laboratory medicine), and LT Scott Wagner, MC (clinical medicine).

RAP winners included LT Daniel Griffin, MC (resident laboratory category); CPT Sarah Placek, MC (resident clinical); Charles P. Xavier, Ph.D. (staff laboratory); and Benjamin Sheffield (staff clinical).

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May 28, 2016

Highlights at the 2016 AUA Annual Meeting in San Diego, Ca

The Center for Prostate Disease Research (CPDR) multi-disciplinary team - together with collaborators - presented 13 abstracts in moderated poster or podium presentations at the American Urological Association (AUA) Annual Meeting, May 6-10, 2016, San Diego, CA. The team was co-led by COL David McLeod, (Ret), MD, CPDR Director and Professor of the Department of Surgery, Uniformed Services University of the Health Sciences (USU) and the Walter Reed National Military Medical Center (WRNMMC); Dr. Shiv Srivastava, CPDR Co-Director and Professor in the Department of Surgery at USU and WRNMMC; COL Inger Rosner, MD, Associate Director, CPDR and Associate Professor, Department of Surgery, USU and the WRNNMC; Dr. Jennifer Cullen, Director of Epidemiology Research Program, CPDR and Research Assistant Professor, Department of Surgery, USU and WRNMMC and Dr. Albert Dobi, Associate Director, CPDR and Research Assistant Professor, Department of Surgery , USU and WRNMMC.

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May 13, 2016


CPDR Student Participant Wins The AACR Gary J. Miller Undergraduate Prize for Cancer and Cancer Related Biomedical Research

A third place prize in the AACR Undergraduate Student Caucus and Poster Competition was awarded to Ms. Shahnoza Dusmatova, a CPDR participant in the DoD "Research and Education Program for Historically Black Colleges and Universities and Minority-Serving Institutions (HBCU/MI)". Her poster was entitled : “Novel Appearance and Clinico-Pathologic Dynamics of TMPRSS2:ERG hybrid Prostate Cancer”. Her mentors include Dr. Kumar (UDC), Dr. Isabell Sesterhenn (JPC), Dr. Jennifer Cullen (CPDR), Dr. Shiv Srivastava (CPDR), and Dr. Taduru Sreenath (CPDR).

Shahnoza Dusmatova (left) with Dr. Rina Das, Ph.D. (National Institute on Minority Health and Health Disparities, Division of Scientific Programs, Office of Research Training and Capacity Building).


May 2, 2016

CPDR Presentations and Highlights at the 2016 AACR Annual Meeting in New Orleans, La.

The Center for Prostate Disease Team has presented their new findings in prostate cancer research at the American Association for Cancer Research Annual Meeting 2016 in New Orleans, Louisiana, USA.

The Team led by Dr. David G. McLeod, Director and Dr. Shiv Srivastava, Co-Director presented the ground breaking discovery of the first recurrent cancer genomic defect of prostate cancers of African American men revealed by whole genome sequencing. The title of the poster presentation was “LSAMP gene deletion is associated with rapid disease progression in prostate cancer of African American men”.

Analyzing the thus far largest and most comprehensive whole mounted prostate cancer specimens for ERG expression, obesity, African American and Caucasian American ethnicity for associations with disease progression the team co-led by Dr. Isabell Sesterhenn and Dr. Jennifer Cullen reported new insights in their poster presentation “ERG-negative index tumor status combined with obesity predict prostate cancer progression in Caucasian American prostate cancer patients”.

Along these lines presentations from the CPDR Team reported initial insights into the development of an ERG-selective inhibitor, ERGi-USU in their poster presentation “ERG oncogene-specific inhibitors for prostate cancer”. Further report from CPDR assessed potential autoantibodies with the long-term goal of prostate cancer diagnosis in the poster presentation “Immunobiomarkers: novel autoantibody panel comprising oncogenic ERG, C-MYC, AMACR and HERV-K Gag for the detection of prostate cancer”.

New insights into the mechanism of ERG action examining in vivo transgenic models of ERG highlighted the role of endoplasmic reticulum stress in the poster presentation of “ERG oncogenic activation leads to the endoplasmic reticulum stress and cell survival mechanisms”.

Poster Presentations:

  • Distinguing features of ERG oncoprotein expression among matched cohorts of African-American and Caucasian-American prostate cancer patients
    Taduru L. Sreenath, Albert Dobi, Shiela S. Macalindong, Natallia Mikhalkevich, Shashwat Sharad, Parameet Kumar, Denise Young, Rishita Gupta, Shilpa Katta, Ahmed Mohamed, Shyh-Han Tan, Gyorgy Petrovics, Charles J. Bieberich, Isabell A. Sesterhenn, Peter Nelson, David G. McLeod, Valeri Vasioukhin, Shiv Srivastava

  • ERGi-USU, A Selective Inhibitor Of ERG Oncogene Positive Cancer Cells
    Ahmed A. Mohamed, Gauthaman Sukumar, Charles P Xavier, Shilpa Katta, Lakshmi Ravindranath, Muhammad Jamal, Taduru Sreenath, David G. McLeod, Gyorgy Petrovics, Meera Srivastava, Albert Dobi, Clifton L. Dalgard and Shiv Srivastava

  • Interaction between ERG Status, Obesity & Race in Predicting Prostate Cancer Progression in a Military Cohort
    Jennifer Cullen, Denise Young, Yongmei Chen, Michael Degon, James Farrell, Jason Sedarsky, Wagner Baptist, Philip Rosen, Vladimir Tolstikov, Michael Kiebesh; Jacob Kagan, Sudhir Srivastava, Huai-Ching Kuo, Joel T. Moncur, Inger L. Rosner, Niven Narain, Viatcheslav Akmaev, Gyorgy Petrovics, Albert Dobi, David G. McLeod, Shiv Srivastava, Isabell A. Sesterhenn

  • LSAMP gene deletion is associated with rapid disease progression in prostate cancer of African American men
    Albert Dobi, Gyorgy Petrovics, Hua Li, Shyh-Han Tan, Tanja Stümpel, Denise Young, Shilpa Katta, Qiyuan Li, Kai Ying, Bernward Klocke, Lakshmi Ravindranath, Indu Kohaar, Yongmei Chen, Dezső Ribli, Korbinian Grote, Hau Zou, Joseph Cheng, Clifton L. Dalgard, Shimin Zhang, István Csabai, Jacob Kagan, David Takeda, Massimo Loda, Sudhir Srivastava, Matthias Scherf, Martin Seifert, Timo Gaiser, David G. McLeod, Zoltan Szallasi, Reinhard Ebner, Thomas Werner, Isabell A. Sesterhenn, Matthew Freedman, Shiv Srivastava

  • Autoantibodies Against ERG, AMACR, C-MYC and HERV-K Gag in the Sera Of Prostate Cancer Patients: Potential Use in Diagnosis/Prognosis
    Anshu Rastogi, Shyh-Han Tan, Amina Ali, Yongmei Chen, Jennifer Cullen, Sreedatta Banerjee, Ahmed A. Mohamed, Lakshmi Ravindranth, Denise Young, Isabell A. Sesterhenn, Jacob Kagan, Sudhir Srivastava, David G. McLeod, Gyorgy Petrovics, Albert Dobi, Shiv Srivastava, Alagarsamy Srinivasan

  • Novel Appearance and Clinico-Pathologic Dynamics of TMPRSS2:ERG Hybrid Prostate Cancer
    Shahnoza Dusmatova, William Gesztes, Lauren Hurwitz, Huai-Ching Kuo, Denise Young, Inger Rosner, Jennifer Cullen, Deepak Kumar, Shiv Srivastava , Isabell Sesterhenn


February 2, 2016

CPDR Urology Residents Take Top Awards at 2016 James C. Kimbrough Urological Seminar

Urology Residents conducting research at The Center for Prostate Disease Research (CPDR), Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center presented their research at the Residents Competition category of the James C. Kimbrough Urological Seminar, San Diego, 2016.

LT Travis Allemang, MD, a fifth-year resident at the Naval Medical Center Portsmouth and Eastern Virginia Medical School, won 1st place for his presentation titled "Prostate Cancer Gene Expression Signatures Associated with Seminal Vesicle Invasion and Biochemical Recurrence after Radical Prostatectomy”. CPT Jason Sedarsky, MD, a fifth-year resident at Urology Service Walter Reed National Military Medical Center won 3rd place for his presentation “Racial Differences of ERG Frequencies in Prostate Cancer. CPT Daniel Kim, MD, a fourth-year Urology Resident presented his research findings on “Patterns in Treatment Decision-Making and Longitudinal Regret for Low Risk Prostate Cancer Patients Managed on Active Surveillance”. Congratulations to all!

Since 1993, CPDR, Department of Surgery, USUHS, and the Urology Service at WRNMMC have been training next-generation urologists and future leaders in the field through the state-of-the-art Urology Resident Training and Education Program. Urology Residents trained at CPDR have been following the great traditions of excellence with their award-winning research work focused on prostate cancer translation research, within the Basic Science Research Program, led by Dr. Shiv Srivastava, Co-Director, CPDR, and Dr. Isabell Sesterhenn, Chief, Genitourinary Pathology at the Joint Pathology Center.

Dr. Albert Dobi, PhD, Associate Director BSRP, CPDR said, “The recognition of these exceptionally innovative research achievements highlight the success of the CPDR multi-disciplinary program and demonstrates the commitment of CPDR, Department of Surgery, USUHS and the WRNMMC to serve DoD patients with prostate cancer by nurturing talents from all arms of the U.S. Armed Forces.”


January 11, 2016

A Novel Gene Alteration Associates with Aggressive Prostate Cancer in African American Men

The USU, Walter Reed-Bethesda and JPC collaborative team, through comprehensive evaluations of matched cohorts of African American and Caucasian American prostate cancers, previously established a higher frequency of ERG alterations in Caucasians (50-70%) and its significantly lower frequency in African Americans (20-25%). These intriguing observations actually provided the rational for the current study focusing on whole genome evaluations of prostate cancers from these two patient populations.

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