The CPDR mission is fulfilled primarily through its three principal programs – the Clinical Research Program, the Basic Science Research Program and the Multicenter National Prostate Cancer Database – and through a robust education and training program that operates out of its Headquarters location, the Clinical Research Center, and the original laboratories at USUHS. CPDR is also committed to patient outreach, primarily through its affiliation with the WRAMC US TOO! organization and through a heavy schedule of health fairs in which it participates.

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> Guest Speaker

CPDR Guest Speaker Seminar

July 1 , 2009
11:00 a.m. - 12:00 p.m.
CPDR - Rockville, MD

Charles J. Bieberich, Ph.D.
Professor, Biological Sciences
University of Maryland Baltimore County
Baltimore, MD

Presenting: “Regulation of NKX3.1 Protein Stability in Prostate Cancer Cells”

The NKX3.1 gene encodes an androgen-regulated homeodomain transcription factor that functions as a prostate-specific tumor suppressor. The NKX3.1 locus at 8p21.2 undergoes frequent loss of heterozygosity in prostate cancer, and diminished protein levels are observed in proliferative inflammatory atrophy, prostatic intraepithelial neoplasia, and carcinoma. In cancer, NKX3.1 protein level is inversely correlated with Gleason grade. Discordance between NKX3.1 mRNA and protein accumulation is observed in a significant proportion of cases, suggesting post-transcriptional or post-translational control. Interestingly, restoration of NKX3.1 protein expression in xenograft and knockout models of prostate cancer suppresses growth.

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> NEWS

CPDR Takes Five Awards

56th Annual James C. Kimbrough Urological Seminar

February 2, 2009

The 56th James C. Kimbrough Urological Seminar brought great recognitions to CPDR. This year the seminar was held in Washington DC.

COL (Ret.) David G.McLeod was honored with the H. G. Stevenson award. In 1992 the Society of Government Service Urologists established this award, which is presented annually for outstanding support and dedicated service to the Society. The recipient of this award can be a Corporate Member, physician, or other individual as determined by the Board of Directors.


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USU’s Center for Prostate Disease Research Provides New Insights Into Common Alterations of ERG Oncogene in Prostate Cancer

Monday, October 6, 2008

BETHESDA, Md. — In the past three years, ground-breaking discoveries in the prostate cancer field have highlighted that alterations of ETS related genes (predominantly ERG), as a result of a fusion between male hormone receptor regulated gene promoters (predominantly TMPRSS2) and ETS transcription factors, represent one of the most common oncogenic defects in prostate cancer. Researchers at the Center for Prostate Disease Research (CPDR) at the Uniformed Services University of the Health Sciences (USU) had originally shown frequent overexpression (60-70%) of the ETS related gene ERG in the epithelial cell transcriptome of prostate cancers. In their continued quest to understand thefunctional role and clinical utility of ERG alterations in prostate cancer, CPDR researchers have now defined new features of ERG function and expression which will further enhance the potential of ERG as promising biomarker and therapeutic target for prostate cancer.

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