BASIC SCIENCE RESEARCH PROGRAM
Research projects are integrated under the following themes which are highly interactive and are beyond the conventional boundaries of a given expertise area and truly represent the CPDR paradigm:
- Translational CaP Genomics and Proteomics
- Novel CaP Cell Culture Models
- CaP Molecular Genetics
- Hormonal Mechanisms of CaP
Translational CaP Genomics and Proteomics
Translational research of cancer cell and molecular biology-derived discoveries in the pre-clinical or clinical research setting has been the priority of CPDR since its inception. A highly multi-disciplinary research environment of urologists, cancer cell and molecular biologists, genitourinary pathologists, bioinformatics and medical informatics experts, bio-statisticians, medical technologists and regulatory affairs experts supports the CPDR enterprise. Well-characterized CPDR biospecimens banks, recent discoveries showing consistent gene expression alterations in CaP and development of promising new molecular diagnostic technologies, have provided an optimal setting for CPDR to focus in the translational research areas, where we already have developed expertise or in the areas where new initiatives are needed.
Novel Cell Culture Models of CaP
The Prostate Cell Center was established in the newly-renovated CPDR laboratory at the Department of Surgery, USUHS, in January 2000 and has been very active over the years. The Prostate Cell Center has made major advances in the generation of short-term cultures from primary tumors of prostate cancer patients. (1) Total cell strains generated from primary tumors are 134, (2) the number of cell strains generated from normal tissue from the same patient are 72, (3) five well-characterized telomerase-immortalized human CaP cell lines from the tumor of African American and caucasian CaP patients. These cells are critical to the development and use of in vitro models and for the identification of novel therapeutic targets of prostate cancer.
CaP Molecular Genetics
Since its inception, CPDR-BRP has embraced the goal of defining CaP-specific genetic alterations that characterize the disease onset and/or progression. Genetic alterations that are "critical" in the genesis of CaP or molecular alterations that "consistently associate" with CaP will provide definitive molecular targets for the development of bio-markers and new therapeutic targets. This goal has become increasingly more apparent as most of the frequent gene alterations associated with other common human cancers such as breast cancer, colon cancer or lung cancer, do not seem to play a significant role in CaP.
Defining Androgen Signaling in CaP Onset and Progression
Androgen signaling is extremely important in the life and death of the prostate gland and is believed to play an important role in prostate cancer. Hormonal therapy, the most common treatment strategy for the treatment of metastatic prostate cancer works by inhibiting androgen signaling. Accumulating evidence suggests that alterations of androgen signaling in prostate cancer may involve structural or functional alterations of the critical genes at numerous points in the pathway.
July 20, 2015
CPDR's GHI publication is featured in the latest MDLinx "Best of Oncology"
MDLinx has featured publication by Dr. Jennifer Cullen, et al., titled: A biopsy-based 17-gene genomic prostate score predicts recurrence after radical prostatectomy and adverse surgical pathology in a racially diverse population of men with clinically low- and intermediate-risk prostate cancer, listed as best of oncology.
Quarterly Guest Speaker
Dr. Stephen Lewis
Radiation Oncologist, WRNMMC
Presentation: "Cancer 101: Understanding Emerging Therapies in 2015"
(Discussion of new treatments in radiation therapy and other modalities including immunotherapies and targeted agents for many cancers).
Date: Thursday, August 6, 2015
Time: 7-8:30 PM
Location: WRNMMC, America Building, 2nd floor, Room 2525
Contact: COL (ret) Jane Hudak for more information at 301-319-2918 or
Read the August 2015 WRNMMC UsToo! Newsletter
April 21, 2014
Biological and Genomic Differences of ERG Oncoprotein-Stratified Prostate Cancers from African and Caucasian Americans
March 30, 2014
CytoTest and Uniformed Services University’s Center for Prostate Disease Research enter into CRADA to advance cancer diagnosis and prognosis