basic sceince research


Innovative Techniques Through Basic Science Research

The Basic Science Research Program (BSRP) focuses on defining prostate cancer-specific molecular alterations that would lead to better understanding of the causes of prostate cancer. Prostate cancer gene discovery and biology focused research efforts are complemented by collaborations from the CPDR's Clinical Research and Multicenter National Database programs, accelerating the evaluations of new biomarkers and therapeutic targets with potential in enhancing the management of prostate cancer.

The program is led by Dr. Shiv Srivastava, who is an internationally recognized leader in the field of cancer research. Strong collaborations with Dr. Isabell A. Sesterhenn from JPC (formerly AFIP) and the CPDR-Clinical Research Program at WRNMMC (formerly WRAMC) remains the mainstay of the highly productive translational research initiatives. Due to the reorganization of the AFIP as JPC, Dr. Sesterhenn's laboratory has been integrated within the CPDR-BSRP as of August 2011.



  • Discovery of frequent and potentially causal prostate cancer gene alterations using cutting edge technologies and well annotated and precisely processed bio-specimens
  • Evaluation of cancer biology of prostate cancer relevant genes or proteins using established and new experimental models
  • Development of new molecular strategies for improving prostate cancer diagnosis (more cancer specific markers than PSA) and prognosis Contents are Proprietary and Provided for CPDR Scientific Advisory Committee Review Only 1: 5
  • Delineation of hormonal mechanisms involved in prostate cancer onset or progression
  • Development and evaluation of novel molecular therapeutic agents for prostate cancer
  • Identification of molecular determinants of prostate cancer susceptibility in high-risk groups such as African-Americans
  • Development and maintenance of long-term molecular specimen resources for translational investigations at CPDR and collaborations at other institutions
  • Education and training of next generation of basic science and translational researchers in prostate cancer


Education and training of medical and graduate students, post-doctoral fellows, residents and visiting scientists in CaP research Two of the major activities of the BRP research program include investigator-initiated research and development of unique bio-resources critical for research at CPDR and in the CaP field.

BSRP Leadership | Gene Expression Data | Research Achievements | BSRP Staff



Quarterly Guest Speaker

Dr. Timothy Tausch

Reconstructive and Prosthetic Urologist at FBCH and WRNMMC

Presentation: "Prostate Cancer Survivorship: Urinary Incontinence After Treatment"

Date: 5 November 2015
Time: 7-8:30 PM
Location: WRNMMC, America Building, 2nd floor, Room 2525
And FBCH via videoteleconference (Oaks Pavilion, 1st floor, room 332)
Contact: COL (ret) Jane Hudak for more information at 301-319-2918 or

Read the August 2015 WRNMMC UsToo! Newsletter

Go to WRNMMC UsToo! Newsletter Archive


July 20, 2015

CPDR's GHI publication is featured in the latest MDLinx "Best of Oncology"


April 21, 2014

Biological and Genomic Differences of ERG Oncoprotein-Stratified Prostate Cancers from African and Caucasian Americans


March 30, 2014

CytoTest and Uniformed Services University’s Center for Prostate Disease Research enter into CRADA to advance cancer diagnosis and prognosis