> Gene Expression Database

Androgen Regulated Transcriptome in Prostate Cancer Cells

Androgen signaling is extremely important in the life and death of the prostate gland and is believed to play an important role (s) in prostate cancer. Hormonal therapy, the most common treatment strategy for the treatment of metastatic prostate cancer works by inhibiting androgen signaling. Accumulating evidence suggests that alterations of androgen signaling in prostate cancer may involve structural or functional alterations of the critical genes at numerous points in the pathway.

Abstract | Genes Defined by SAGE | Genes Defined by Gene Chip | ARE Data

P53 Regulated Genes in Prostate Cancer Cells

P53 is an important tumor suppressor gene, which induces cell growth arrest or apoptosis when subjected to cytotoxic stimuli. Association has been reported between various cancers and p53 codon 72 polymorphism.

Abstract | Tables/Figures

Prostate Cancer Associated Genes

Transcription factors encoded by the ETS family of genes are central in integrating signals that regulate cell growth and differentiation, stress responses and tumorigenesis. This study, analyzing laser microdissected paired benign and malignant prostate epithelial cells from prostate cancer (CaP) patients (n=114; 228 specimen) by GeneChip and quantitative real time RT-PCR, identifies ERG, a member of the ETS transcription factor family, as the most frequently overexpressed proto-oncogene in the transcriptome of malignant prostate epithelial cells. Combined quantitative expression analysis of ERG with two other genes commonly overexpressed in CaP, AMACR and DD3, revealed overexpression of at least one of these three genes in virtually all CaP specimen (54 of 55). Comprehensive evaluation of quantitative ERG1 expression with clinico-pathological features also suggested that ERG1 expression level in prostate tumor cells relative to benign epithelial cells is indicator of disease free survival after radical prostatectomy.

Abstract | Tables/Figures